Sumatra Pasak Bumi is a distributor of Asian medicinal herbs, with a focus on plant extracts that have been used for ages in Asia to enhance the sexual function and sexual pleasure of men and women. Our initial focus was on tongkat ali, which we have been distributing since last century. Our principal website is still named tongkatali.org, and our company is registered as Sumatra Pasak Bumi (pasak bumi is the Indonesian name for tongkat ali).
Indonesia only has one additional maleness-enhancing herbal, daun bungkos, but that one doesn’t work on the hormonal pathway but is used for penis enlargement. We source it in Papua New Guinea, some 6000 kilometers away.
We sell a whole lot of other herbals, from Indonesia and China, that support not sexual parameters but general health. However, our pioneering efforts have always been in the sexual arena where herbal enhancement is most rewarding, especially for men.
We have scouted and sourced all over Asia, but the country richest in male-supporting biodiversity is Thailand. So it’s maybe not accidentally that Thailand has long been a paradise for men in other aspects than herbal medicine.
Thailand isn’t integrated into the Western World to the same degree as Indonesia. Thailand never was a colony of a European power, and doesn’t use the Roman alphabet, so scientific research into Thai ethnobotany was scarce. This, however has changed, and there is now solid scientific research backing traditional knowledge that butea superba and grachai dam can revive a man’s sex life, and make good sex extraordinarily fantastic.
We have distributed butea superba more than 10 years ago, but only as a sideline. Recent research has made it a necessity to put it on a track parallel to tongkat ali.
Antidepressant-like effect of Butea superba in mice exposed to chronic mild stress and its possible mechanism of action
Butea superba (BS) is a Thai medicinal plant that has been used as a folk medicine to improve physical and mental conditions and to prevent impaired sexual performance in middle-aged or elderly males. We have previously reported that this plant extract could improve cognitive deficits and depression-like behavior in olfactory bulbectomized mice, an animal model of dementia and depression.
Aim of the study
In this study we examined the effect of BS on depression-like behavior in mice subjected to unpredictable chronic mild stress (UCMS) to clarify the antidepressant-like activity of BS and the molecular mechanism underlying this effect.
Materials and methods
UCMS mice were administered BS daily (300 mg of dried herb weight/kg, p.o.) or a reference drug, imipramine (IMP, 10 mg/kg, i.p.), 1 week after starting the UCMS procedure. We employed the sucrose preference test and the tail suspension test to analyze anhedonia and depression-like behavior of mice, respectively. Serum and brain tissues of mice were used for neurochemical and immunohistochemical studies. The UCMS procedure induced anhedonia and depression-like behavior, and BS treatment, as well as IMP treatment, attenuated these symptoms. UCMS caused an elevation of serum corticosterone level, an index of hyper-activation of the hypothalamic–pituitary–adrenal (HPA) axis, in a manner attenuated by BS and IMP treatment. BS treatment also attenuated UCMS-induced decrease in the expression levels of brain-derived neurotrophic factor (BDNF) mRNA, cyclic AMP-responsive element binding protein (CREB) and a phosphorylated form of N-methyl-d-aspartate receptor subunit NR1, synaptic plasticity-related signaling proteins. Moreover, the UCMS procedure reduced doublecortin-positive cells in the dentate gyrus region of the hippocampus. BS administration reversed these UCMS-induced neurochemical and histological abnormalities.
These results suggest that BS can ameliorate chronic stress-induced depression-like symptoms and that the effects of BS are mediated by restoring dysfunctions of the HPA axis and synaptic plasticity-related signaling systems and neurogenesis in the hippocampus.